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No significant changes in the baseline concentrations of NAD + and its metabolites in whole human blood were observed even after 16 wk of treatment with the same dose of NMN [140]

The study group comprised 80 healthy subjects aged 2165 years

Ethical approval The use of zebrafish and chicken embryos were approved by the Ethics Committee for Animal Care and Use in Scientific Research from the Federal University of Rio de Janeiro (Comisso de tica no Uso de Animais em Pesquisas da Universidade Federal do Rio de Janeiro (CEUA, UFRJ) and received the approval numbers 028/25 (zebrafish) and 081/22 (chicken)

All of these factors can contribute to poor production of glutathione (or of the enzymes that help glutathione to do its work), and many also deplete the GSH that the cells produce (by converting it into GSSG)