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In the hyperhomocysteinemia-induced endothelial impairment model in rats, similar findings were reported [59]

Doxycycline, a semi-synthetic tetracycline, has greater lipophilicity than older tetracyclines, which confers advantages such as high oral bioavailability and a wide volume of distribution in animals (1, 2)

Chronic daily glutathione supplementation in the absence of deficiency may downregulate endogenous synthesis through negative feedback on gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione production

Coyle P, Philcox J, Carey L, Rofe A (2002) Metallothionein: the multipurpose protein

Rituximab, a monoclonal antibody targeting the CD20 antigen, depletes CD20-positive B lymphocytes through antibody-dependent cell-mediated cytotoxicity (ADCC), complement-mediated cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and programmed cell death (PD), providing a robust rationale for its use in treating SLE (114, 115)