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Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease

F., Lin, G

In addition, with the growing insights into the production and utilization of one-carbon units in cancer cells, multiple therapeutic strategies have been proposed, including nutrient therapy and targeting enzymes in one-carbon metabolism pathways

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It also shows how environmental factors like infections and toxins amplify this dysregulation, and how functional testing can illuminate root contributors and guide targeted interventions