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peaks during dose escalation, typically mild-moderate Diarrhea -- 10-20%, usually transient Constipation -- 8-15% Vomiting -- 5-15%, more frequent at higher doses Injection site reactions -- 5-10%, mild erythema and pruritus Decreased appetite -- 5-12%, related to mechanism of action Pancreatitis -- rare but monitored (as with all GLP-1/amylin agents) Gallbladder events -- cholelithiasis reported, consistent with rapid weight loss Trial data describes dose titration as central to tolerability -- the 16-week escalation protocol substantially reduced GI adverse events
I have just completed my first month on Tirzepatide which resulted in a 10 pound weight loss
5 This can have significantly detrimental effects on the nervous system, cell division, and other methylation processes
Methylcobalamin or vitamin B12 improves mood, energy, increases appetite and can help alleviate depression