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Carotenoids are incredibly powerful antioxidants and are known as the most potent physical quencher of singlet oxygen [164]

High-dose NAC (1,200 milligrams per day) may also help lower inflammation, break up biofilms where germs live, and lessen damage caused by oxidative stress in the lungs and airways of people with cystic fibrosis, when used alone or with other medications

Neurology 2003;60:1284-9.ArticlePubMed 51

Mouse lines To generate the Ccrk flox mouse line, we subcloned an 11.5-kb Ccrk genomic fragment using C57BL/6 genomic DNA by PCR, inserted one loxP site into intron 2 and another loxP site into intron 4, cloned it into a modified pBluescript II KS (+) vector (Agilent) to make a targeting construct, and transfected the linearized targeting construct into the JM8A3 embryonic stem cell line (94)