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Mitochondrial DNA(mtDNA) is vulnerable to oxidative stress, resulting in both qualitative and quantitative changes

It modulates inflammation by regulating the production of pro-inflammatory and anti-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-) and interleukin-10 (IL-10) (Drge & Breitkreutz, 2000)

The anticonvulsant drugs phenobarbital, phenytoin (Dilantin), and carbamazepine (Tegretol) may also lower plasma vitamin E concentrations in individuals with epilepsy (129)

Consistency works better than aggressive treatments