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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

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Current Evidence and Clinical Practice Patterns Limited prospective trials directly evaluate GLP-1 plus phentermine in the same cohort

J Immunol (Baltimore Md: 1950) (2018) 201(11):334351