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Vaporciyan AA, Rice DC, Correa AM, Walsh GL, Swisher SG , Smythe WR, Putnam JB, Roth JA

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First, FFAs create a high-oxidative state that triggers the release of calcium ions (Ca + ) from the ER, which increases intracellular Ca + concentrations and retroactively activates various digestive enzymes, including trypsin ( Clinical studies have indicated that patients with hypertriglyceridemia-induced AP often experience more severe abdominal pain, higher fever, and markedly increased levels of inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) ( Another important aspect of the link between hypertriglyceridemia and necrotizing pancreatitis is the role of genetic factors