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James Hetfield said in a statement about the song, "'Screaming Suicide' addresses the taboo word of suicide

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E-cigarette aerosol particulates consist largely of aqueous droplets and vapors of humectants, either PG or glycerol, whereas particulates in combustible tobacco smoke are complex, largely organic constituents that contain polycyclic aromatic hydrocarbons and a variety of other known or suspected carcinogens

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