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The altered DNA base can cause errors during DNA replication that have mutagenic and carcinogenic potential

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It expands on information included in the first edition by addressing more recent demographic data, greater emphasis on the importance of cultural competence and understanding the role of culture in both dynamics and treatment, and current evidence-based and best practices

Combiner Once the rods are manufactured, they are moved to the combiner where they are cut to the expected length, and combined with the other components, such as the hollow acetate tube, cellulose-acetate mouthpiece filter, and outer and mouth-end papers