The clefts could be caused by any number of chemicals but one possibility may be diacetyl, a compound that results in the buttery taste, but is shown to be bad for humans. If diacetyl is indeed one of the e-liquid compounds that causes clefts, it would not be its only danger when inhaled, researchers said
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The proportion of e-cig users in early middle age increased by more than half between 2016 to 2018, according to Mintel research
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